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We leverage one of the largest de-identified linked patient databases in the U.S. to help people live healthier lives. The topics we explore are as broad as the challenges in health care today. These insights inform our action. Here’s a sample of our work.

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Study Snapshots

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Hearing loss treatment

Learn about the health consequences and costs associated with untreated hearing loss.

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doctor speaking to patient

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Complementing RCTs with real-world evidence

OptumLabs partners pair real-world data with clinical trials to improve A-fib treatment. 

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Doctor using a stethescope on his patient

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Projects in motion

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Conservative therapies for low back pain
APTA, Boston University, UHC

How do initial care patterns for evaluation and treatment of new-onset low back pain, including provider type and service type, influence the risk of short- and long-term opioid use and misuse? Insights may inform new benefit and network designs related to back pain.

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STI testing, infections, and treatment
Centers for Disease Control and Prevention

Using linked clinical and claims data, what are the national testing, infection and treatment rates for STIs such as chlamydia, gonorrhea and syphilis? Findings can enhance current STI surveillance and health services research methodology.

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Predicting Alzheimer’s and dementia 
University of Maryland, Baltimore; OptumLabs

Can we look back at patient history — years before a dementia diagnosis — to find early warning signs? Through claims-based regression models, machine learning models and natural language processing of clinical data, we hope to predict dementia sooner.

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Antidepressant use during pregnancy
University of California, San Diego

Are certain antidepressant use patterns associated with poor pregnancy or birth outcomes? Findings can help mothers and doctors make informed decisions about their mental health management.

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Diffusing clinical evidence to practice
UMN, Harvard, Yale, Mayo Clinic

Looking at large RCTs and FDA safety warnings that reveal ineffective and unsafe treatments, what factors impact de-implementation across care delivery systems? This question is key for improving patient safety and outcomes while speeding up value-based change in care.

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Insurance policy impact on cancer care
Stand Up To Cancer

Has the Dependent Coverage Provision - which allows young adults to stay on their parents' health insuance plan until 26 yrs - led to more cancer patients 18-25 yrs getting follow-up care? 

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Publications