We leverage one of the largest de-identified linked patient databases in the U.S. to help people live healthier lives. The topics we explore are as broad as the challenges in health care today. These insights inform our action. Here’s a sample of our work.
Study Snapshots
Projects in motion
Dose tapering in chronic opioid users
University of California, Davis
How frequently are patients prescribed long-term opioids having their doses tapered, and is dose tapering associated with differences in risk of opioid overdose, adverse mental health outcomes, and chronic disease outcomes? By better understanding the benefits and harms associated with tapering, this project may improve the quality and safety of care for patients prescribed long-term opioids.
Anticholinergic (ACh) use in older adults
AARP
Cholinesterase inhibitors (ChEI) are used to treat dementia, but taking ChEIs with many ACh drugs prescribed for common conditions reduces ChEIs’ effectiveness and may accelerate cognitive decline. By looking at prescribing patterns, outcomes, and cost of combining ChEIs with AChs, we could improve quality of care.
Disparities in CDHP financial strain
Johns Hopkins University
Consumer-directed health plans (CDHPs) with high deductibles have grown in popularity, but what is the effect of these plans on personal financial strain and do the effects vary by socioeconomic status? The results could help employers understand the implications of switching to CDHPs.
Antidepressant use during pregnancy
University of California, San Diego
Are certain antidepressant use patterns associated with poor pregnancy or birth outcomes? Findings can help mothers and doctors make informed decisions about their mental health management.
Diffusing clinical evidence to practice
UMN, Harvard, Yale, Mayo Clinic
Looking at large RCTs and FDA safety warnings that reveal ineffective and unsafe treatments, what factors impact de-implementation across care delivery systems? This question is key for improving patient safety and outcomes while speeding up value-based change in care.
STI testing, infections, and treatment
Centers for Disease Control and Prevention
Using linked clinical and claims data, what are the national testing, infection and treatment rates for STIs such as chlamydia, gonorrhea and syphilis? Findings can enhance current STI surveillance and health services research methodology.